American researchers have developed an experimental mRNA vaccine capable of activating the immune system against various types of tumors. This is reported by ScienceAlert with reference to a study by the University of Florida.
The drug is based on mRNA encoding signaling proteins. These proteins act as a “warning signal” for the body, making tumor cells more vulnerable and attracting the attention of immune cells, which usually do not respond to cancer.
According to neurologist Dwayne Mitchell, the new approach allows for the formation of a powerful antitumor response, not limited to a specific type of cancer. In combination with immune control point inhibitors — drugs that remove the “brake” from the immune system — the vaccine showed the strongest effect. In experiments on mice, some tumors completely disappeared, including those that were previously considered resistant to treatment.
Scientists note that interfering with the work of the immune system is associated with the risk of side effects, but the first results look promising. Now the team is working on improving the formula of the drug and preparing for clinical trials on humans.
